Acute liver failure – Symptoms and causes – Mayo Clinic
Acetaminophen overdose. Taking too much acetaminophen (Tylenol, others) is the most common cause of acute liver failure in the United States. Acute liver failure can occur after one very large dose of acetaminophen, or after higher than recommended doses every day for several days.
If you or someone you know has taken an overdose of acetaminophen, seek medical attention as quickly as possible. Don’t wait for the signs of liver failure.
Prescription medications. Some prescription medications, including antibiotics, nonsteroidal anti-inflammatory drugs and anticonvulsants, can cause acute liver failure.