1754 Inoculation for smallpox introduced in Rome. The practice was soon stopped because of the number of deaths it caused. Later, the medical profession would successfully reintroduce it.
1763 Epidemic of smallpox in France wipes out a large part of the population. It was immediately attributed to inoculation, and the practice was prohibited by the French government for five years.
1763 The first recorded episode of biological warfare in the United States occurs when white colonial settlers give smallpox-infected blankets to Native Americans who sought friendly relations. Also a significant case of genocide.
1791 Edward Jenner vaccinates his 18 month old son with swine-pox. In 1798, he vaccinates his son with cow-pox. His son will die of TB at the age of 21.
1796 Edward Jenner in Gloucestershire, England, credited with concept of vaccination. Jenner vaccinates an 8 year old boy with smallpox pus. Jenner would vaccinate the boy 20 times. The boy would die from TB at the age of 20.
1857 Vaccination in England enforced by fines. Smallpox epidemic begins in England that lasts until 1859 when over 14,000 die.