…A recent meta-analysis suggests that in patients with severe sepsis and ARDS, vitamin C lessens both the duration of mechanical ventilation and the length of ICU stay. In a recent randomized clinical trial of 167 patients with sepsis and ARDS, treatment with high-dose intravenous vitamin C up to 15 g per day was associated with a significant reduction in 28-day mortality and a shortened duration of ICU stay.
According to a 2017 review of vitamin C and immune function, epidemiological studies have indicated that hypovitaminosis C (i.e., plasma vitamin C less than 23 mmol/L) is relatively common in Western populations, and vitamin C deficiency (less than 11 mmol/L) is the fourth leading nutrient deficiency in the U.S.
The 2007-2010 U.S. National Health and Nutrition Examination Survey of approximately 16,000 children and adults found that almost 40% had low levels of vitamin C, while 88% of the U.S. population did not meet the daily requirement for vitamin E (noted to enhance the effects of vitamin C).
The case authors conclude that their report highlights the potential benefits of high-dose intravenous vitamin C in critically ill COVID-19 patients in terms of rapid recovery and shortened length of mechanical ventilation and ICU stay, and urge further research.‘Unusual’ IV High-Dose Vitamin C Success Story in COVID-19 | MedPage Today