Current interim CDC guidance states individuals with a history of allergic reaction to vaccines or any injectable therapies should consider deferral of vaccination or consult with an allergist/immunologist, and should be observed for 30 minutes. Any individual with a history of anaphylaxis unrelated to vaccines or injectable therapies should be observed for 30 minutes, while those with a history of unrelated allergies should be observed for 15 minutes.
Median interval from vaccine administration to symptom onset was 7.5 minutes, and while nine patients had symptom onset within 15 minutes, one had symptom onset after 30 minutes. Interestingly, the report focusing on the Pfizer/BioNTech vaccine found a median interval to symptom onset of about 13 minutes.
They added that vaccine administration sites should have providers available to recognize signs of anaphylaxis, administer epinephrine, and transport patients to facilities where they can receive care.Anaphylaxis Cases With Moderna COVID-19 Vax Follow Similar Pattern | MedPage Today