Griffin: That’s correct. I think people are unfortunately familiar with adenoviruses. These are the common cold viruses and, you know, I think all of us, at some point, at far too many points, you know, you’ve had the sniffle. You’ve had the cough. You felt crummy. If it’s a cold it’s often adenovirus.
But here with Sputnik, with the AstraZeneca and the J&J, they’re using slightly different adenoviruses. So, there are a number of adenoviruses. You can take an adenovirus from a chimpanzee, and that’s what they’re using at AstraZeneca. They took a chimp adenovirus, the original ChAdOx.
AstraZeneca didn’t do that. So it actually is this post-fusion change. And it’s not clear to me. I don’t think we know yet whether or not AstraZeneca was a little less effective because of that, or because it has to do with the delivery system they’re using, the chimp adenovirus.What Do We Really Know About Adenovirus Vectors for Vaccines? | MedPage Today