What Do We Really Know About Adenovirus Vectors for Vaccines? | MedPage Today

Griffin: That’s correct. I think people are unfortunately familiar with adenoviruses. These are the common cold viruses and, you know, I think all of us, at some point, at far too many points, you know, you’ve had the sniffle. You’ve had the cough. You felt crummy. If it’s a cold it’s often adenovirus.

But here with Sputnik, with the AstraZeneca and the J&J, they’re using slightly different adenoviruses. So, there are a number of adenoviruses. You can take an adenovirus from a chimpanzee, and that’s what they’re using at AstraZeneca. They took a chimp adenovirus, the original ChAdOx.

AstraZeneca didn’t do that. So it actually is this post-fusion change. And it’s not clear to me. I don’t think we know yet whether or not AstraZeneca was a little less effective because of that, or because it has to do with the delivery system they’re using, the chimp adenovirus.

What Do We Really Know About Adenovirus Vectors for Vaccines? | MedPage Today