Antibody-dependent Enhancement (ADE) and Vaccines | Children’s Hospital of Philadelphia

ADE occurs when the antibodies generated during an immune response recognize and bind to a pathogen, but they are unable to prevent infection. Instead, these antibodies act as a “Trojan horse,” allowing the pathogen to get into cells and exacerbate the immune response.

Antibody-dependent Enhancement (ADE) and Vaccines | Children’s Hospital of Philadelphia