In the 1955 Cutter Incident, some batches of polio vaccine given to the public contained live poliovirus—even though they had passed the required safety testing. More than 250 cases of polio were attributed to vaccines produced by one company, Cutter Laboratories. The mistake resulted in many cases of paralysis, and the vaccine was recalled as soon as new cases of polio were detected.
In 2017, the Philippines stopped a school-based dengue fever vaccination program after reports of complications and several deaths linked to the product called Dengvaxia. The French manufacturer, Sanofi Pasteur, later stated that the vaccine posed a risk to those without prior infection from one of the disease’s four stereotypes. The result was that it actually increased the risk that a child would contract a more severe form of the disease.
The final case deals with the vaccination attempt of the respiratory syncytial virus (RSV). Children treated with one type of vaccine in the 1960s developed an enhanced form of the disease, often suffering from high fever, bronchopneumonia and wheezing. Dozens ended up being hospitalized and two died. There still is no vaccine to prevent RSV infection, but scientists are working hard to develop one, according to the CDC.Four Times in History Vaccines Failed (Lessons for a Coronavirus Vaccine?) | The National Interest