Ivermectin itself for ascariasis, demodicosis, gnathostomiasis, hookworm-related cutaneous larva migrans, lice, mansonella ozzardi infection, mansonella streptocerca infection, scabies, trichuriasis, and wucheria bancrofti infection (try telling someone with lice or scabies they can’t use a curative course of IVM because it’s off-label and thus unproven and too dangerous).
Ibuprofen for gout and pericarditis (if you’ve had gout you don’t need the FDA telling you high dose ibuprofen works – it’s rather obvious).
Wellbutrin/Bupropion for smoking cessation.
Neurontin/Gabapentin for bipolar, essential tremor, hot flashes, migraine prevention, neuropathic pain, phantom limb syndrome, and restless leg syndrome.
Magnesium sulfate for premature labor and preeclampsia.
Seroquel for insomnia.
Zoloft for premature ejaculation.
None of these would be used if, above all, practical experience, and after that many small, underpowered and somewhat flawed studies, did not show they worked. Overall around 20% of medications prescribed to the general population are off-label and up to 90% of what’s prescribed to newborns has never been studied and is off-label – we literally have no evidence of it’s benefit outside of educated speculation – because who wants to subject newborns to a placebo controlled trial?
After an exhaustive review of published medical research on therapeutic procedures like surgery and medication, the prestigious Cochrane Review concluded that about 10% of what doctor’s do is based on high quality evidence and another 37% on moderate quality evidence. Meaning just over 50% of modern medical practice is based on low or very low quality evidence.COVID-19: The Frontline Online | Dr. Syed Haider