Tromethamine Side Effects – Drugs.com

Carefully supervise dosage and rate of administration to avoid overtreatment (alkalosis). Determine blood pH, arterial oxygen pressure (PaO2), carbon dioxide tension (PaCO2), bicarbonate, glucose and electrolyte concentrations, and urinary output before, during, and following administration of the drug. Monitor dosage and progress of treatment, as needed.

Possible local irritation and tissue inflammation or infection at the site of injection, febrile response, chemical phlebitis, venospasm, hypervolemia, and IV thrombosis.

Tromethamine Monograph for Professionals – Drugs.com