Chinese Load Cow’s Milk with mRNA Exosomes–Successfully Immunize Mice

The nation’s food supply can be manipulated by public health agencies to influence population outcomes. A great is example is fortification of cereal grains with folic acid — the synthetic form of folate — which successfully reduced the incidence of neural tube defects (e.g. spina bifida). Now an oral route of administration is being considered specifically for COVID-19 vaccination using mRNA in cow’s milk.

Zhang and colleagues have demonstrated that a shortened mRNA code of 675 base pairs could be loaded into phospholipid packets called exosomes derived from milk and then using that same milk, be fed to mice. The mice gastrointestinal tract absorbed the exosomes and the mRNA must have made it into the blood stream and lymphatic tissue because antibodies were produced in fed mice against SARS-CoV-2 Spike protein (receptor binding domain).

petermcculloughmd Chinese Load Cow’s Milk with mRNA Exosomes–Successfully Immunize Mice